Tyk2-IN-18
Tyk2-IN-18 (compound 86) is a potent tyrosine kinase 2 (Tyk2) inhibitor. Tyk2-IN-18 inhibits JAK2-JH2, with an IC50 of [1][2].
Product Specifications
CAS Number
[3024860-29-2]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyk2-in-18.html
Smiles
COCCOC1=CC(C(F)(F)C)=NC(N2CC3(C4=C2C=C(N=C4)NC(C)=O)CC3)=C1
Molecular Formula
C21H24F2N4O3
Molecular Weight
418.44
References & Citations
[1]Ram W. Sabnis. Novel Tyrosine Kinase 2 Inhibitors for Treating Autoimmune and Inflammatory Diseases. ACS Med. Chem. Lett. May 16, 2024.|[2]Jeffrey Vessels, et al. Tyrosine kinase 2 inhibitors and uses thereof. WO2023250064A1. 2023-12-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tyk2
Curated Selection
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