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GPRP

GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) [1][2].

Product Specifications

CAS Number

[67869-62-9]

Product Name Alternative

Gly-Pro-Arg-Pro; Pefa 6003

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gprp.html

Purity

99.89

Solubility

DMSO : 66.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H]2N(C(CN)=O)CCC2)=O)=O)CCC1

Molecular Formula

C18H31N7O5

Molecular Weight

425.48

References & Citations

[1]Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78 (6) :547-50.|[2]Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24 (3) : 322-7.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Res Pract Thromb Haemost. 2025 Sep 24.|Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.|Platelets. 2025 Dec;36 (1) :2517108.

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