DOTA-PEG5-azide
DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dota-peg5-azide.html
Purity
98.0
Solubility
H2O : 175 mg/mL (ultrasonic)
Smiles
O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(NCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)O
Molecular Formula
C28H52N8O12
Molecular Weight
692.76
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
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