A83-01
ALK kinase inhibitor
Product Specifications
Background
A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.
CAS Number
909910-43-6
Product Name Alternative
3- (6-Methyl-2-pyridinyl) -N-phenyl-4- (4-quinolinyl) -1H-pyrazole-1-carbothioamide, A-83-01, A83-01
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
White to beige powder
Solubility
Soluble to 50 mM in DMSO
Molecular Formula
C25H19N5S
Molecular Weight
421.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Li W., et al. (2009) Stem Cell 4(1): 16–19. 2. Cherukuri P., et al. (2012). PloS One. 7(11): e50066.
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