Tunicamycin
Autophagy inducer
Product Specifications
Background
As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy (1-4). Triggers a-synuclein oligomerization, dopaminergic neurons death and locomotor impariement, potentially a model for Parkinson's Disease (5).
CAS Number
11089-65-9
Product Name Alternative
Tunicamycin from Streptomyces sp.
UNSPSC
41116105
Type
Inducer
Source
Isolated from Streptomyces lysosuperficus
Field of Research
Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
>98% (HPLC) as a mixture of tunicamycin A, B, C and D
Weight
0.025
Format
White solid.
Solubility
Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).
Molecular Formula
C39H64N4O16
Molecular Weight
844.95
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14.
2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.
3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.
4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35. 5. Coppola-Segovia V., et al. (2016) Molecular Neuro. 54, 5798-5806.
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