BIX-01294
HMT inhibitor
Product Specifications
Background
G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
CAS Number
935693-62-2
Product Name Alternative
2- (Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1- (phenylmethyl) -4-piperidinyl]-4-quinazolinamine trihydrochloride; N- (1-Benzyl-4-piperidinyl) -6,7-dimethoxy-2- (4-methyl-1,4-diazepan-1-yl) -4-quinazolinamine trihydrochloride
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>98%
Weight
0.025
Format
Cream solid
Solubility
May be dissolved in DMSO (100 mM) or Water (100 mM)
Molecular Formula
C28H38N6O2*3HCl
Molecular Weight
600.02
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481.
2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574.
3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.
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