Pyr-41
Ubiquitin-Activating Enzyme (E1) Inhibitor
Product Specifications
Background
Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 µM) with little or no activity against E2 or E3. Cell permeable.
CAS Number
418805-02-4
Product Name Alternative
Ethyl 4-{ (4Z) -4-[ (5-nitro-2-furyl) methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4- (5-Nitro-furan-2-ylmethylene) -3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.005
Format
Brown Powder
Solubility
Soluble in 25 mg/ml DMSO
Molecular Formula
C17H13N3O7
Molecular Weight
371.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yang Y., et al. (2007) Cancer Res. 67: 9472. 2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.
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