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Cibenzoline (succinate)

Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline. Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities[1].

Product Specifications

CAS Number

100678-32-8

Product Name Alternative

Cifenline (succinate) ; Ro 22-7796 (succinate)

UNSPSC

12352005

Hazard Statement

H302

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cibenzoline-succinate.html

Smiles

O=C(O)CCC(O)=O.C1(C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2)=NCCN1

Molecular Formula

C22H24N2O4

Molecular Weight

380.44

Precautions

P264-P270-P330-P501

References & Citations

[1]Mukai E, et al., The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998 Oct 20;251 (2) :477-81.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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