Amyloid Oligomers (A11) Antibody
Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal
Product Specifications
Background
Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
Specifications
Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Product Name Alternative
Neuroscience, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Amyloid
UNSPSC
12352203
Gene ID
8666
Swiss Prot
P05067
Accession Number
NM_000484.2
Cellular Locus
Membrane
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Eukaryote
Immunogen
Synthetic molecular mimic of soluble human amyloid beta oligomers
Target
Amyloid Oligomers (A11)
Clonality
Polyclonal
Conjugation
Unconjugated
Validated Applications
WB,IHC,ICC/IF,IP,ELISA
Purification
Protein A Purified
Dilution
The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.
2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.
3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Product MSDS
https://cdn.gentaur.com/products/400/4414309/msds/spc-506d.pdf
CAS Number
9007-83-4
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