K114
K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI) [2].
Product Specifications
CAS Number
[872201-12-2]
UNSPSC
12171500
Hazard Statement
H319-H413
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/k114.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3
Molecular Formula
C22H17BrO2
Molecular Weight
393.27
Precautions
P264-P273-P280-P305+P351+P338-P501
References & Citations
[1]LeVine H 3rd, et al. Mechanism of A beta (1-40) fibril-induced fluorescence of (trans, trans) -1-bromo-2,5-bis (4-hydroxystyryl) benzene (K114) . Biochemistry. 2005 Dec 6;44 (48) :15937-43.|[2]Selmani V, et al. K114 (trans, trans) -bromo-2,5-bis (4-hydroxystyryl) benzene is an efficient detector of cationic amyloid fibrils. Protein Sci. 2015 Mar;24 (3) :420-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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