(R) -Bambuterol
(R) -Bambuterol is a β2-receptor agonist with anti-asthmatic and colitis-improving activity. (R) -Bambuterol is indicated for the treatment of asthma and chronic obstructive pulmonary disease and has the advantage of a once-daily dosing and a favorable side effect profile. (R) -Bambuterol significantly reduced disease severity in a mouse model of colitis, more effectively than (RS) -Bambuterol or (S) -Bambuterol. (R) -Bambuterol can significantly reduce the levels of inflammatory cytokines and reduce the infiltration of macrophages in mice with colitis. (R) -Bambuterol also increases β2-adrenoceptor levels and reduces the expression of IL-6, IL-17 and other related proteins in colon tissue in a dose-dependent manner[1].
Product Specifications
CAS Number
788821-30-7
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-bambuterol.html
Smiles
CC(C)(C)NC[C@@H](C1=CC(OC(N(C)C)=O)=CC(OC(N(C)C)=O)=C1)O
Molecular Formula
C18H29N3O5
Molecular Weight
367.44
References & Citations
[1] (RS) -bambuterol and its enantiomers: Potential improvement of (R) -bambuterol in mice with colitis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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