IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1 (R132H) /IDH2 (R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/idh1-2-in-1.html
Smiles
O=S(C1=CC=C(NC2=NC(NC3=CC=C(OC)C=C3)=NC(N/N=C/C4=CC(OC)=C(OC)C(OC)=C4)=N2)C=C1)(N)=O
Molecular Formula
C26H28N8O6S
Molecular Weight
580.62
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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