Recombinant LRP1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712) . This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Abbreviation
LRP1
UniProt
Q07954
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human LRP1 protein
Target
TGFBR; LRP1; A2MR; APOER; APR; CD91; IGFBP3R; KPA; LRP; LRP1A; TGFBR5; &alpha-2M-R-R; LRP
Clonality
Monoclonal,Recombinant
Clone
5A9
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Neuroscience; Cardiovascular; Cell Biology; Signal Transduction; Metabolism; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000; WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/C1czvpEU
Calculated Molecular Weight
85 kDa
Observed Molecular Weight
85 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
