SB-656104
SB-656104 is a potent antagonist of 5-HT7 receptor, with the pKi of 8.70, blocking 5-carboxamidotryptamine (5-CT) stimulated adenylyl cyclase activity[1].
Product Specifications
CAS Number
446020-51-5
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-656104.html
Smiles
O=S(N1[C@H](CCC1)CCN2CCC(CC2)OC3=CC=C(C=C3)Cl)(C4=CC=C(C=CN5)C5=C4)=O
Molecular Formula
C25H30ClN3O3S
Molecular Weight
488.04
References & Citations
[1]Ian T Forbes, et al. SB-656104-A: a novel 5-HT7 receptor antagonist with improved in vivo properties. Bioorg Med Chem Lett. 2002 Nov 18;12 (22) :3341-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor
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