Squoxin

Squoxin (ST1859) is an antiamyloid agent that specifically binds to Aβ1-42 and prevents the aggregation and fibril formation of Aβ. Squoxin crosses the blood-brain barrier (BBB) and has anthelmintic activity and anti-inflammatory properties[1].

Product Specifications

CAS Number

[1096-84-0]

Product Name Alternative

ST1859; 1,1′-Methylenedi-2-naphthol

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/squoxin.html

Solubility

10 mM in DMSO

Smiles

C1=CC=C2C(=C1)C=CC(=C2CC3=C(C=CC4=CC=CC=C43)O)O

Molecular Formula

C21H16O2

Molecular Weight

300.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Martin Bauer, et al. A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease. Clin Pharmacol Ther. 2006 Sep;80 (3) :216-27.