APX879
APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 analog, which maintains broad-spectrum antifungal activity[1][2].
Product Specifications
CAS Number
1801372-27-9
UNSPSC
12352005
Target
Calcineurin; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/apx879.html
Purity
95.36
Smiles
CO[C@@H]1[C@]2([H])O[C@]([C@@H](C1)C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](C/C([C@@H](/C=C(C[C@@H](C[C@@H]2OC)C)\C)CC=C)=N/NC(C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)O
Molecular Formula
C46H73N3O12
Molecular Weight
860.08
References & Citations
[1]Gobeil SM, et al. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 Dec 21;12 (6) :e0300021.|[2]Hoy M J. Development of Novel Antifungal Compounds for the Treatment of Systemic Fungal Infections[D]. Duke University, 2022.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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