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Apoptosis inducer 28

Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Protease Activated Receptor (PAR) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptosis-inducer-28.html

Smiles

O=C(NC1=CC=C(/N=C2C(NC3=C\2C=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=C1Cl)C5=CC(Cl)=CC=C5O

Molecular Formula

C26H22Cl2N4O5S

Molecular Weight

573.45

References & Citations

[1]Omran M M, et al. Pharmacological investigation of new niclosamide-based isatin hybrids as antiproliferative, antioxidant, and apoptosis inducers[J]. Scientific Reports, 2024, 14 (1) : 19818.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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