Apoptosis inducer 28
Product Specifications
UNSPSC Description
Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4[1].
Target Antigen
Apoptosis; Bcl-2 Family; Protease Activated Receptor (PAR); Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-28.html
Smiles
O=C(NC1=CC=C(/N=C2C(NC3=C\2C=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=C1Cl)C5=CC(Cl)=CC=C5O
Molecular Weight
573.45
References & Citations
[1]Omran M M, et al. Pharmacological investigation of new niclosamide-based isatin hybrids as antiproliferative, antioxidant, and apoptosis inducers[J]. Scientific Reports, 2024, 14(1): 19818.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169124/Apoptosis-inducer-28-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169124/
Clinical Information
No Development Reported
Curated Selection
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