53BP1 (phospho-Ser1778) rabbit pAb
Product Specifications
Product Name Alternative
Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
UniProt
Q12888
Swiss Prot
Q12888
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized phosho peptide around human 53BP1 (Ser1778)
Target
53BP1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:1000-2000
Buffer
-20°C/1 year
Molecular Weight
213kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
213kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136) . Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs) : recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600) . Associated with kinetochores during mitosis (By similarity) . .
Other Product Names
Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene ID (Human)
7158
Available Sizes
Curated Selection
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