Cynomolgus Mucin-1 / MUC-1 Protein, Fc Tag

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The mature Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved N-terminal fragment and C-terminal fragment. Each N-terminal fragment and C-terminal fragment has a calculated MW of 7.2 kDa and 32.8 kDa. The protein migrates as 48 kDa (precursor protein) and 40-45 kDa (C-terminus) under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

XP_005541632.1

Expression Region

Leu 254 - Gly 373

Host

HEK293

Target

Mucin-1

Conjugation

Unconjugated

Tag

C-Fc

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.