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AQP2 rabbit pAb

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008],

Product Specifications

Background

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Synonyms

AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct

Gene ID

359

UniProt

P41181

Cellular Locus

Apical cell membrane ; Multi-pass membrane protein. Basolateral cell membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein. Cytoplasmic vesicle membrane ; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein. Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity)..

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Monkey,Dog

Reactivity

Human; Mouse; Rat; Monkey; Dog

Immunogen

The antiserum was produced against synthesized peptide derived from human Aquaporin 2. AA range:222-271

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC, IF, ELISA

Validated Applications

WB,IHC,IF,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

29kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1688-1.pdf

Observed Molecular Weight

29 kD

Subcellular Location

Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Shuttles from vesicles to the apical membrane (PubMed:15509592) . Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592) . PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity) . .

Other Product Names

AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct

Gene ID (Human)

359

SwissProt (Human)

P41181

Available Sizes

Curated Selection

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