RI-OR2-TAT
Product Specifications
CAS Number
1430219-69-4
Target
Others, Beta Amyloid
Related Pathways
Others, Neuroscience
Bioactivity
RI-OR2-TAT is a brain-penetrable inhibitor targeting β-amyloid (β-Amyloid) oligomerization. It is engineered by integrating the HIV protein transduction domain TAT into RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. It reduces Aβ aggregation and plaque levels, diminishes microglial activation and oxidative damage, and enhances the number of young neurons in the dentate gyrus.
Smiles
[C@H](CC1=CC=CC=C1)(NC([C@@H](CC2=CC=CC=C2)NC(CNC([C@@H](CCCNC(=N)N)NC(C)=O)=O)=O)=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@H](CC3=CC=C(O)C=C3)C(N)=O)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCCN)=O)CC(C)C)=O)[C@@H](C)C)=O
Molecular Formula
C117H201N49O23
Molecular Weight
2662.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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