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Aldose Reductase rabbit pAb

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009],

Product Specifications

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Synonyms

AKR1B1; ALDR1; Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1

Gene ID

231

UniProt

P15121

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Rat

Reactivity

Human; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human AKR1B1. AA range:241-290

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC, IF, ELISA

Validated Applications

WB,IHC,IF,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

36kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES1641-1.pdf

Observed Molecular Weight

36 kD

Subcellular Location

Cytoplasm.

Other Product Names

AKR1B1; ALDR1; Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1

Gene ID (Human)

231

SwissProt (Human)

P15121

Available Sizes

Curated Selection

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