MEK4 (F194) Rabbit pAb
SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction .
Product Specifications
Background
Product Name Alternative
JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1
UniProt
P45985
Swiss Prot
P45985
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1mg/mL
Dilution
WB 1:1,000-2,000
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
44kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
44kDa
Fragment
IgG
Subcellular Location
Cytoplasm, Nucleus
Other Product Names
JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1
Gene ID (Human)
6416
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Cytokeratin, HMW Antibody (rKRTH/8883) [Alexa Fluor 594]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
Mouse Monoclonal Cytokeratin, HMW Antibody (rKRTH/8883) [Alexa Fluor 594]
