TrkA, Rat (HEK293, His)

The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, His) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rat (HEK293, His) is 386 a.a., with molecular weight of ~70-95 kDa.

AASCRETCCP VGPSGLRCTR AGTLNTLRGL RGAGNLTELY VENQRDLQRL EFEDLQGLGE LRSLTIVKSG LRFVAPDAFH FTPRLSHLNL SSNALESLSW KTVQGLSLQD LTLSGNPLHC SCALLWLQRW EQEDLCGVYT QKLQGSGSGD QFLPLGHNNS CGVPSVKIQM PNDSVEVGDD VFLQCQVEGQ ALQQADWILT ELEGTATMKK SGDLPSLGLT LVNVTSDLNK KNVTCWAEND VGRAEVSVQV SVSFPASVHL GKAVEQHHWC IPFSVDGQPA PSLRWFFNGS VLNETSFIFT QFLESALTNE TMRHGCLRLN QPTHVNNGNY TLLAANPYGQ AAASIMAAFM DNPFEFNPED PIPVSFSPVD TNSTSRDPVE KKDETP