Methyl 2-amino-5-bromobenzoate

Methyl 2-amino-5-bromobenzoate (Compound 8/12) is a biochemical reagent. Methyl 2-amino-5-bromobenzoate can be used to synthesize 2-benzamidobenzoic acid, a known FabH inhibitor. Derivatives of methyl 2-amino-5-bromobenzoate also inhibit PqsD, the pqs quorum sensing (QS) system, of Pseudomonas aeruginosa[1].

Product Specifications

CAS Number

[52727-57-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Drug Intermediate

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Methyl_2-amino-5-bromobenzoate.html

Purity

99.73

Solubility

DMSO : ≥ 300 mg/mL

Smiles

COC(C1=C(N)C=CC(Br)=C1)=O

Molecular Formula

C8H8BrNO2

Molecular Weight

230.06

Precautions

H315, H319, H335

References & Citations

[1]Weidel E, et al. Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking. J Med Chem. 2013 Aug 8;56 (15) :6146-55.