NSC109116
NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone. NSC109116 is a salicylic compound that selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2. It potently inhibits the metabolism of progesterone in bovine aortic endothelial cells overexpressing AKR1C1 with an IC₅₀ of 460 nM.
Product Specifications
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months
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319818 100 µL
HSD17B11 (HSD17B11, DHRS8, PAN1B, Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase XI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2)
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