Zotepine

Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].

Product Specifications

CAS Number

[26615-21-4]

UNSPSC

12352005

Hazard Statement

H301, H410

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zotepine.html

Purity

99.80

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1

Molecular Formula

C18H18ClNOS

Molecular Weight

331.86

Precautions

H301, H410

References & Citations

[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68 (1) :29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157 (4) :656-65.