PTP1B-IN-3

PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects[1][2].

Product Specifications

CAS Number

[809272-64-8]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PTP1B-IN-3.html

Purity

99.35

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

BrC1=C(C(F)(P(O)(O)=O)F)C=C2C(C=CC(C#N)=C2)=C1

Molecular Formula

C12H7BrF2NO3P

Molecular Weight

362.06

References & Citations

[1]Patel D, .Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors. ChemMedChem. 2011 Jun 6; 6 (6) :1011-6.|[2]Yongxin Han, et al. Discovery of [ (3-bromo-7-cyano-2-naphthyl) (difluoro) methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. Bioorg Med Chem Lett. 2008 Jun 1;18 (11) :3200-5.