Citropten
Product Specifications
UNSPSC Description
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis[1] [2] [3].
Target Antigen
ERK; JNK; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/citropten.html
Purity
99.41
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1OC2=C(C(OC)=CC(OC)=C2)C=C1
Molecular Weight
206.197
References & Citations
[1]Wolny D, et al. Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells. Acta Pol Pharm. 2014 Nov-Dec;71(6):1056-9.|[2]Lee HS, et al. Ameliorative Effect of Citropten Isolated from <i>Citrusaurantifolia</i> Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis. Molecules. 2022 Jul 20;27(14):4633.|[3]Yang W, et al. 5,7-Dimethoxycoumarin prevents chronic mild stress induced depression in rats through increase in the expression of heat shock protein-70 and inhibition of monoamine oxidase-A levels. Saudi J Biol Sci. 2018 Feb;25(2):253-258.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N7085/Citropten-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N7085/Citropten-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
487-06-9
Available Sizes
Curated Selection
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