Cdk5i peptide
Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases[1].
Product Specifications
CAS Number
2298317-00-5
UNSPSC
12352209
Target
CDK
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cdk5i-peptide.html
Purity
99.83
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C60H94N18O15S
Molecular Weight
1339.56
References & Citations
[1]Pao PC, et al. A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A. 2023 Apr 18;120 (16) :e2217864120.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CDK5
Available Sizes
Frequently Asked Questions
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