Cdk5i peptide

Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases[1].

Product Specifications

CAS Number

[2298317-00-5]

UNSPSC

12352209

Target

CDK

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cdk5i-peptide.html

Purity

99.83

Solubility

DMSO : 2 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C60H94N18O15S

Molecular Weight

1339.56

References & Citations

[1]Pao PC, et al. A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A. 2023 Apr 18;120 (16) :e2217864120.