Ponatinib (AP24534)

943319-70-8

3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide

TGF-β Smad Signaling Bcr-Abl Tyrosine Kinase Bcr-Abl Tyrosine Kinase FGFR Tyrosine Kinase FLT3 Tyrosine Kinase PDGFR Tyrosine Kinase VEGFR

0.9992

A solid

≥53.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

C29H27F3N6O

532.56

Blue ice

Store at -20°C.