(±) -ML 209
(±) -ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±) -ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±) -ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±) -ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1].
Product Specifications
CAS Number
[1334526-14-5]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/racemic-ml-209.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C[C@@H]1C)C[C@H](C1)C)CC(C2=CC=C3C(OCO3)=C2)C(C(O)=CC(OC)=C4)=C4OC
Molecular Formula
C25H31NO6
Molecular Weight
441.52
References & Citations
[1]Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4 (1) :79-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
Available Sizes
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