Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Amuvatinib (Standard)

Amuvatinib (Standard) is the analytical standard of Amuvatinib. This product is intended for research and analytical applications. Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair[1][2][3]. Antineoplastic activity[4].

Product Specifications

CAS Number

850879-09-3

Product Name Alternative

MP470 (Standard) ; HPK 56 (Standard)

UNSPSC

12352005

Target

Apoptosis; c-Kit; c-Met/HGFR; FLT3; PDGFR; RAD51; Reference Standards; RET

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

S=C(N1CCN(C2=C3OC4=CC=CC=C4C3=NC=N2)CC1)NCC5=CC=C6OCOC6=C5

Molecular Formula

C23H21N5O3S

Molecular Weight

447.51

References & Citations

[1]Choy G, et al. Safety, tolerability, and pharmacokinetics of amuvatinib from three phase 1 clinical studies in healthy volunteers. Cancer Chemother Pharmacol. 2012 Jul;70 (1) :183-90.|[2]Baxter PA, et al. Plasma and cerebrospinal fluid pharmacokinetics of MP470 in non-human primates. Cancer Chemother Pharmacol. 2011 Apr;67 (4) :809-12.|[3]Tibes R, et al. A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Feb;71 (2) :463-71.|[4]David J. Bearss, et al. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same. US20080226747A1.|[5]Qi W, et al. MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer. BMC Cancer. 2009 May 11;9:142.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Angle Rotor, 6 x 100 ml
EQ40-ART100 1 Each

Angle Rotor, 6 x 100 ml

Sign In for Pricing
View Details
Rabbit Polyclonal RND3 Antibody [Alexa Fluor 405]
NBP2-98843AF405 0.1 mL

Rabbit Polyclonal RND3 Antibody [Alexa Fluor 405]

Sign In for Pricing
View Details
SNX30 ORF Vector (Human) (pORF)
ORF033154 1.0 µg DNA

SNX30 ORF Vector (Human) (pORF)

Sign In for Pricing
View Details
LYRM7 Knockout HT29 Polyclonal Cells
ARG13942 1 Million

LYRM7 Knockout HT29 Polyclonal Cells

Sign In for Pricing
View Details
Adprhl1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K6358208 1.0 µg DNA

Adprhl1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

Sign In for Pricing
View Details
Chn1 (NM_029716) Mouse Tagged Lenti ORF Clone
MR215993L4 10 µg

Chn1 (NM_029716) Mouse Tagged Lenti ORF Clone

Sign In for Pricing
View Details