Dimethyl itaconate

Dimethyl itaconate induces innate immune memory (trained immunity), and exhibits immunomodulatory property. Dimethyl itaconate inhibits the activation of microglia, reduces the neuroinflammation and synaptic structural damage. Dimethyl itaconate regulates the composition of intestinal flora[1][2].

Product Specifications

CAS Number

[617-52-7]

UNSPSC

12352200

Hazard Statement

H315, H334, H401

Target

Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dimethyl-itaconate.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C(C(C(OC)=O)=C)C(OC)=O

Molecular Formula

C7H10O4

Molecular Weight

158.15

Precautions

H315, H334, H401

References & Citations

[1]Ferreira AV, et al., Dimethyl itaconate induces long-term innate immune responses and confers protection against infection. Cell Rep. 2023 Jun 27;42 (6) :112658.|[2]Pan W, et al., Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice. Microbiome. 2023 Feb 21;11 (1) :30.