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T100-Mut

T100-Mut is a cell-permeable peptide whose N-terminus is conjugated with a myristoylated group to enable T100-Mut to penetrate and localize to the inner side of the plasma membrane, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-mediated pain[1].

Product Specifications

UNSPSC

12352209

Target

TRP Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/t100-mut.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(N)=O)=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CO)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O

Molecular Formula

C161H271N49O42S

Molecular Weight

3597.30

References & Citations

[1]Weng HJ, et al. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015 Feb 18;85 (4) :833-46.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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