JH-VIII-49
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518) [1][2].
Product Specifications
CAS Number
[2209084-73-9]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
CDK; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh-viii-49.html
Smiles
C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1
Molecular Formula
C30H40N2
Molecular Weight
428.65
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8
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