EGFR-IN-36
Product Specifications
UNSPSC Description
EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-36.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1CC(C2=CC(C3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)=C5C(N)=NC=NN52)CCC1)=O
Molecular Weight
488.97
References & Citations
[1]Yihan Wang, et al. Substituted acrylamide derivatives and their compositions and uses. WO2021185348A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144053/EGFR-IN-36-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144053/
Clinical Information
No Development Reported
CAS Number
2711105-54-1
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