PF-06751979
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
Product Specifications
CAS Number
1818339-66-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-06751979.html
Purity
99.23
Solubility
DMSO : 150 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
FC(F)OC1=CN=C(C(NC2=CSC([C@]34CO[C@@H](C)C[C@@]3([H])CSC(N)=N4)=N2)=O)C=C1
Molecular Formula
C18H19F2N5O3S2
Molecular Weight
455.50
Precautions
H302, H315, H319, H335
References & Citations
[1]O'Neill BT, et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61 (10) :4476-4504.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
BACE1
Available Sizes
Frequently Asked Questions
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