Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SB-328437

SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU -resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases[1][2][3].

Product Specifications

CAS Number

247580-43-4

UNSPSC

12352005

Hazard Statement

H302, H400

Target

CCR; Thymidylate Synthase

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-328437.html

Purity

99.58

Solubility

DMSO : 87.5 mg/mL (ultrasonic)

Smiles

O=C(OC)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=C3C=CC=CC3=CC=C2)=O

Molecular Formula

C21H18N2O5

Molecular Weight

378.38

Precautions

H302, H400

References & Citations

[1]White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275 (47) :36626-31. |[2]Gutiérrez Á, et al. Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights. Oncol Lett. 2024 May 1;28 (1) :296.|[3]Lopez-Leal F, et al. Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation. J Leukoc Biol. 2024 Nov 4;116 (5) :1198-1207.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CCR3

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]
E-AB-F1316M-01 20 Tests

Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]
E-AB-F1316M-02 100 Tests

Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]
E-AB-F1316M-03 2x 100 Tests

Elab Fluor® 647 Anti-Human CD11a Antibody[HI111]

Sign In for Pricing
View Details
Wheat Germ Coated - 96 well plates - 8 Well Breakable Strips on single well holding frame - Black PS
MGB11F2-WG/W 10x 96 Well Plates

Wheat Germ Coated - 96 well plates - 8 Well Breakable Strips on single well holding frame - Black PS

Sign In for Pricing
View Details
EIF2B5 Recombinant Rabbit Monoclonal Antibody [JE34-98]
HA722206 100 µL

EIF2B5 Recombinant Rabbit Monoclonal Antibody [JE34-98]

Sign In for Pricing
View Details
Cathepsin Z (CTSZ) Rabbit Monoclonal Antibody [Clone ID: R09-9J9]
TA422136 100 µL

Cathepsin Z (CTSZ) Rabbit Monoclonal Antibody [Clone ID: R09-9J9]

Sign In for Pricing
View Details