1,5-Isoquinolinediol
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
Product Specifications
CAS Number
[5154-02-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/1-5-isoquinolinediol.html
Purity
99.14
Solubility
DMSO : 37.04 mg/mL (ultrasonic)
Smiles
O=C1NC=CC2=C1C=CC=C2O
Molecular Formula
C9H7NO2
Molecular Weight
161.16
Precautions
H315, H319, H335
References & Citations
[1]Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1358906 1.0 µg DNA
MTCP1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
MPXV-0321 100 µg
Recombinant Monkeypox Virus C20.5L Protein, IMV Protein
Sign In for Pricing
View Details MBS6139103-01 0.1 mL
SLC25A18 (Mitochondrial Glutamate Carrier 2, GC-2, Glutamate/H(+) Symporter 2, Solute Carrier Family 25 Member 18, GC2) APC
Sign In for Pricing
View Details MBS6139103-02 5x 0.1 mL
SLC25A18 (Mitochondrial Glutamate Carrier 2, GC-2, Glutamate/H(+) Symporter 2, Solute Carrier Family 25 Member 18, GC2) APC
Sign In for Pricing
View Details 
RR204337L4V 200 µL
Kti12 (NM_001044288) Rat Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details