Stearoyl-L-carnitine-d3 (chloride)
Product Specifications
UNSPSC Description
Stearoyl-L-carnitine-d3 (chloride) is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].
Target Antigen
Endogenous Metabolite; GlyT
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Metabolic Disease
Purity
99.80
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C([2H])([2H])[2H])=O.[Cl-]
Molecular Weight
467.14
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One. 2016 May 19;11(5):e0155694.|[3]Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902.|[4]Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58(8):1361-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Clinical Information
No Development Reported
CAS Number
2245711-27-5
Available Sizes
Curated Selection
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