Proxyphylline

Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1].

Product Specifications

CAS Number

[603-00-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Adenosine Receptor; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Proxyphylline.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N1C)N(C)C2=C(N(CC(O)C)C=N2)C1=O

Molecular Formula

C10H14N4O3

Molecular Weight

238.25

Precautions

H302

References & Citations

[1]Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27 (5) :709-20.|[2]Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33 (10) :1450-4.|[3]Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65 (1) :20-7.|[4]Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh) . 1982 Sep;51 (3) :250-2.