WDR5 degrader-1

WDR5 degrader-1 (compound 25) is a cereblon (CRBN) -recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1[1].

Product Specifications

CAS Number

[3032434-45-7]

UNSPSC

12352005

Target

PROTACs; WDR5

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wdr5-degrader-1.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1[C@@H](CN(C2=C(C=C(C=C2)C3=CC(C(NCCCCCCCNC(COC4=C(C5=CC=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)=O)=CC=C3F)NC(C7=CNC(C=C7C(F)(F)F)=O)=O)C[C@@H]1C)C

Molecular Formula

C49H52F4N8O9

Molecular Weight

972.98

References & Citations

[1]Xufen Yu, et al. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. J Med Chem. 2023, 66, 23.