Recombinant Human BMP-2 Protein (Trx Tag)
Product Specifications
Background
Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer, 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.
Abbreviation
BMP-2
Synonyms
BDA2; BMP-2; BMP-2A; Bmp2; BMP2; BMP2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
UniProt
P12643
Accession Number
P12643
Expression System
E.coli
Tag
N-Trx
Sequence
Gln283-Arg396
Field of Research
Signal Transduction; Stem Cells; Cancer; Cardiovascular
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
32.4 kDa
Observed Molecular Weight
32 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC880894-500 1x 500 µL
Melanoma Marker (PNL2), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNCB2335-500 1x 500 µL
TIMP2 (Tissue Inhibitor of Metalloproteinase 2) (rTIMP2/2335), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![C1S Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI5F2]](https://cdn.genprice.uk/products/937/6868c34e994c49e6dc3f42ef/imageurl/ta504245bm.webp)
TA504245BM 100 µL
C1S Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI5F2]
Sign In for Pricing
View Details 
