XStAx-VHLL (TFA)

XStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1].

Product Specifications

UNSPSC

12352209

Target

PROTACs; Wnt; β-catenin

Type

Peptides

Related Pathways

PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xstax-vhll-tfa.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCNC(N)=N)NC(C)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H]4CC(O)=O)=O)=O)=O)(CCC/C=C/CCC[C@@](C(N[C@@H](CC5=CN=CN5)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N8[C@H](C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H]([C@@H](C)CC)C(N%10[C@H](C(N)=O)CCC%10)=O)=O)=O)CCC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)(NC4=O)C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C154H244N48O29.xC2HF3O2

Molecular Weight

3231.89 (free base)

References & Citations

[1]Hongwei Liao, et al. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9:6:35.