xStAx-VHLL (TFA)
Product Specifications
UNSPSC Description
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1].
Target Antigen
PROTACs; Wnt; β-catenin
Type
Peptides
Related Pathways
PROTAC;Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xstax-vhll-tfa.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCCNC(N)=N)NC(C)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H]4CC(O)=O)=O)=O)=O)(CCC/C=C/CCC[C@@](C(N[C@@H](CC5=CN=CN5)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N8[C@H](C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H]([C@@H](C)CC)C(N%10[C@H](C(N)=O)CCC%10)=O)=O)=O)CCC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)(NC4=O)C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Weight
3231.89 (free base)
References & Citations
[1]Hongwei Liao, et al. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9:6:35.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5819A/xStAx-VHLL-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5819A/xStAx-VHLL-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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