Dizocilpine
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux[1][2].
Product Specifications
CAS Number
[77086-21-6]
Product Name Alternative
MK-801
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dizocilpine-free-base.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]1(N2)C3=CC=CC=C3C[C@]2([H])C4=CC=CC=C14
Molecular Formula
C16H15N
Molecular Weight
221.30
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Citation 01
Available Sizes
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