ASP2535
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1].
Product Specifications
CAS Number
374886-51-8
UNSPSC
12352005
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/asp2535.html
Purity
99.44
Solubility
DMSO : 3.9 mg/mL (ultrasonic)
Smiles
CC(C1=NN=C(C2=CC=C(C3=CC=CC=C3)N=C2)N1C4=CC=CC5=NON=C54)C
Molecular Formula
C22H18N6O
Molecular Weight
382.42
References & Citations
[1]Harada K, et al. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5- (6-phenyl-3-pyridyl) -4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Eur J Pharmacol. 2012 Jun 15;685 (1-3) :59-69.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GlyT1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC402547-100 1x 100 µL
NKX2.8 (NKX28/2547), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882746-500 1x 500 µL
PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) (PDL1/2746), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![IL-31 Mouse Monoclonal Antibody [B7-B0]](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea8142e/imageurl/m1305-3.webp)