Akt1-IN-1
Akt1-IN-1 (compound 5b) is a potent and selective Akt1 inhibitor with an IC50 value of 18.79 nM in MIA Paca-2 cells. Akt1-IN-1 does not exhibit obvious teratogenicity, hepatotoxicity and cardiotoxicity (No Observed Adverse Effect Level > 100 µM) . Akt1-IN-1 can be used for researching anticancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt1-in-1.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=C(C=C1)S(=O)(N2C(COCC3=C(N=C(N=C3C(C)C)N(S(C)(=O)=O)C)C4=CC=C(F)C=C4)=CC5=CN=CC=C52)=O
Molecular Formula
C31H32FN5O5S2
Molecular Weight
637.74
References & Citations
[1]Kumar JS, et al. Ultrasound assisted one-pot synthesis of rosuvastatin based novel azaindole derivatives via coupling-cyclization strategy under Pd/Cu-catalysis: Their evaluation as potential cytotoxic agents. Bioorg Chem. 2022;124:105857.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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