Tioxolone
Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis[1][2][3].
Product Specifications
CAS Number
4991-65-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Carbonic Anhydrase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tioxolone.html
Purity
98.83
Solubility
DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)
Smiles
O=C1OC2=CC(O)=CC=C2S1
Molecular Formula
C7H4O3S
Molecular Weight
168.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Maryam Hakimi Parizi, et al. Tioxolone niosomes exert antileishmanial effects on Leishmania tropica by promoting promastigote apoptosis and immunomodulation. Asian Pacific Journal of Tropical Medicine 2019; 12 (8) : 365-374.|[2]Parizi M H, et al. Tioxolone niosomes exert antileishmanial effects on Leishmania tropica by promoting promastigote apoptosis and immunomodulation[J]. Asian Pacific Journal of Tropical Medicine, 2019, 12 (8) : 365-374.|[3]Prajapat S K, et al. Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux[J]. Autophagy Reports, 2022, 1 (1) : 523-536.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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