Tioxolone

Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis[1][2][3].

Product Specifications

CAS Number

[4991-65-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Carbonic Anhydrase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tioxolone.html

Purity

98.83

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)

Smiles

O=C1OC2=CC(O)=CC=C2S1

Molecular Formula

C7H4O3S

Molecular Weight

168.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Maryam Hakimi Parizi, et al. Tioxolone niosomes exert antileishmanial effects on Leishmania tropica by promoting promastigote apoptosis and immunomodulation. Asian Pacific Journal of Tropical Medicine 2019; 12 (8) : 365-374.|[2]Parizi M H, et al. Tioxolone niosomes exert antileishmanial effects on Leishmania tropica by promoting promastigote apoptosis and immunomodulation[J]. Asian Pacific Journal of Tropical Medicine, 2019, 12 (8) : 365-374.|[3]Prajapat S K, et al. Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux[J]. Autophagy Reports, 2022, 1 (1) : 523-536.