ISRIB
Product Specifications
UNSPSC Description
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research[1][2][3].
Target Antigen
Biochemical Assay Reagents; Eukaryotic Initiation Factor (eIF)
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage;Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isrib.html
Purity
98.58
Solubility
DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
Molecular Weight
451.34
References & Citations
[1]Zyryanova AF, et al. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol Cell. 2021 Jan 7;81(1):88-103.e6.|[2]Halliday M, et al. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis. 2015 Mar 5;6(3):e1672.|[3]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife. 2015 Feb 26;4:e05033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12495A/ISRIB-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12495A/ISRIB-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
548470-11-7
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
